E2375

Sigma

 

Emetine dihydrochloride hydrate

CAS Number:316-42-7
Linear Formula:C29H40N2O4 · 2HCl · xH2O
Molecular Weight:553.56 (anhydrous basis)
Beilstein Registry Number:5216794
EC Number:206-259-8
MDL number:MFCD00149309
PubChem Substance ID:24278410

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Reviews

Description

ApplicationApoptosis inducer

Properties

mp240-250 °C (dec., dry matter)(lit.)
storage temp.2-8°C

Safety

Hazard CodesT+
Risk Statements28-36/37/38
Safety Statements26-28-36/37-45
RIDADRUN 1544 6.1/PG 1
WGK Germany3
RTECSJY5250000

References

referenceMeijerman I, et al., Induction of apoptosis and changes in nuclear G-actin are mediated by different pathways: the effect of inhibitors of protein and RNA synthesis in isolated rat hepatocytes. Toxicol. Appl. Pharmacol. 156(1), 46-55, (1999)
 Hikawa, N., and Takenaka, T., Method for production of neuronal hybridoma using emetine and actinomycin D. Brain Res. Brain Res. Protoc. 1, 224-226, (1997)
 Galasinski W., et al., The substances of plant origin that inhibit protein biosynthesis. Acta Pol. Pharm. 53, 311-318, (1996) Abstract
 Boon-Unge, K., et. al., Emetine regulates the alternative splicing of Bcl-x through a protein phosphatase 1-dependent mechanism. Chem. Biol. 14, 1386-1392, (2007) Abstract
MerckMerck 13,3591
BeilsteinBeil. 23,IV,3419